Therapeutic Drug Monitoring

Therapeutic Drug Monitoring

Development and application of analytical methods for therapeutic drug monitoring

Therapeutic drug monitoring (TDM) subsumes the surveillance of medically prescribed drugs in patients. Toxicological analytical methods play a major role in TDM, as the determination of the substances as well as their quantification in biological samples allow conclusions concerning compliance or metabolism characteristics and, therefore, effectiveness of the given drug. Especially for substances that show a small therapeutic range or for newly launched drugs TDM is essential for a safe clinical appliance. The analysis of drug concentrations in different tissues (e.g. blood, plasma, urine, saliva) helps to find optimal application routes and to minimize unwelcome side effects.

With our TDM lab we are involved in several scientific projects. To provide reliable quantitative data, validated assays employing state-of-the-art LC/MS or GC/MS technology are used. A number of assays are available for immediate application. For other targets an assay development service is provided. Please contact Herbert Oberacher for more information.

Scientific studies

The following publications provide examples for the successful application of our analytical expertise to scientific studies:

  1. Welte, R., Oberacher, H., Gasparetti, T., Pfister, H., Griesmacher, A., Santner, T., Lass-Flörl, C., Hörtnagl, C., Leitner-Rupprich, S., Aigner, M., Lorenz, I., Schmid, S., Edlinger, M., Eller, P., Dankl, D., Joannidis, M., Bellmann, R. Pharmacokinetics and Antifungal Activity of Echinocandins in Ascites Fluid of Critically Ill Patients Antimicrobial Agents and Chemotherapy, 65 (2021), e0256520.
  2. Gasparetti, T., Welte, R., Oberacher, H., Marx, J., Lorenz, I., Schellengowski, P., Staudinger, T., Burgmann, K., Eller, P., Santner, T., Griesmacher, A., Pfister, H., Eschertzhuber, S., Aigner, M., Joannidis, M., Bellmann, R. Penetration of Echinocandins into Wound Secretion of Critically Ill Patients Infection 49 (2021), 747-755.
  3. Welte, R., Oberacher, H., Schwärzler, B., Joannidis, M., Bellmann, R. Quantification of Anidulafungin and Micafungin in Human Body Fluids by High Performance-Liquid Chromatography with UV-Detection Journal of Chromatography B, 1139 (2020), 121937.
  4. Bohn, J.-P., Reinstadler, V., Pall, G., Stockhammer, G. Steurer, M., Oberacher, H. Wolf, D.* Cerebrospinal Fluid Drug Concentrations and Clinical Outcome of Patients with Neoplastic Meningitis Treated with Liposomal Cytarabine European Journal of Drug Metabolism and Pharmacokinetics, 44 (2019), 845-851.
  5. Bohn, J.-P., Willenbacher, W., Haas, G., Peschel, I., Oberacher, H., Steurer, M.
    Pomalidomide in Primary Intraocular Lymphoma Leukemia & Lymphoma, 60 (2019), 1584-1586.
  6. Bohn, J.-P., Willenbacher, W., Peschel, I., Oberacher, H., Steurer, M.
    Second-generation Immunomodulatory Drugs in Leptomeningeal Myeloma Leukemia & Lymphoma, 60 (2019) 550-552.
  7. Bonengel, S., Jelkmann, M., Abdulkarim, M., Gumbleton, M., Reinstadler, V., Oberacher, H., Prüfert, F., Bernkop-Schnürch, A.
    Impact of Different Hydrophobic Ion Pairs of Octreotide on its Oral Bioavailability in Pigs
    Journal of Controlled Release, 10 (2018), 21-29.
  8. Ortner, N. J., G. Bock, G., Dougalis, A., Kharitonova, M., Duda, M., J., Tuluc, P., Pomberger, T., Stefanova, N., Pitterl, F., Ciossek, T., Oberacher, H., Draheim, H. J., Liss, B., Striessnig, J.
    Lower Affinity of Isradipine for L-type Ca2+ Channels during Substantia Nigra Dopamine Neuron-like Activity: Implications for Neuroprotection in Parkinson’s Disease
    The Journal of Neuroscience, 37 (2017), 6761-6777.
  9. Scharinger, B., Messner, B., Türkcan, A., Schuster, D., Vuorinen, A., Pitterl, F., Heinz, K., Arnhard, K., Laufer, G., Grimm, M., Stuppner, H., Oberacher, H., Eller, P., Ritsch, A., Bernhard, D.
    Leoligin, the Major Lignan from Edelweiss, Inhibits 3-hydroxy-3-methyl-glutaryl-CoA Reductase and Reduces Cholesterol Levels in ApoE -/- Mice
    Journal of Molecular and Cellular Cardiology, 99 (2016), 35-46.
  10. Erb, R., Leithner, K., Bernkop-Schnürch, A., Oberacher, H.
    Phosphorothioate Oligonucleotide Quantification by Micro Liquid Chromatography - Mass Spectrometry
    AAPS Journal, 14 (2012), 728-737.
  11. Beer, B., Schubert, B., Oberguggenberger, A., Meraner, V., Hubalek, M., Oberacher, H.
    Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Quantification of Tamoxifen, Anastrozole and Letrozole in Human Plasma and its Application to a Clinical Study
    Analytical and Bioanalytical Chemistry, 398 (2010), 1791-1800.